Glutathione bukan sekadar Mencerah



APA ITU GLUTHATHIONE??


Glutathione merupakan tripeptida iaitu tiga protein dalam satu molekul (cystein, glutamin acid dan glycin). Glutathione secara alami terdapat dan terhasil dalam tubuh setiap individu. Tetapi, seiring dengan lanjutnya usia, semakin berkuranglah kadar Glutathione yang menyebabkan kesihatan optimal tidak tercapai, secara fisik, psikis dan sosial.

Glutathione berperan penting dalam sistem kekebalan tubuh, regenerasi sel, bersifat antioksidan dan anti toksin. Kadar Glutathione dalam tubuh merupakan indikator untuk membezakan antara individu yang sihat dengan yang individu berpenyakit.Diberi jolokan


sebagai MASTER ANTIOKSIDAN kerana telah diakui oleh para ahli perubatan antarabangsa bahawa belum ada antioksidan lain yang mampu menyamai kekuatannya. 


Banyak fungsi sel-sel tubuh yang bergantung pada Glutathione seperti :Berkurangnya Glutathione menyebabkan daya tahan tubuh berkurang, fungsi organ tubuh terganggu, otot-otot kaku, timbul penyakit degeneratif (parkinson, kepikunan, tremor, dll), muncul tanda-tanda penuaan (kedut, rambutgugur/beruban, pigmentasi, kulit kusam dll).Tanpa Glutathione antioksidan lain seperti Vitamin C & E tidak bekerja optimal.

Tanpa Glutathione, tubuh tidak dapat menghasilkan antibodi untuk melawan infeksi bakteria, virus & polusi.Tanpa Glutathione, proses penyeimbangan radikal bebas di dalam tubuh tidak akan tercapai. Kesan radikal bebasakan merosak dinding sel tubuh yang menyebabkan timbulnya penyakit, seperti kanser dan belbagai penyakit degeneratif lain.

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"Glutathione, the Ultimate Antioxidant"

Natural production of glutathione occurs only intracellularly. Most of glutathione is used inside the cells for antioxidant defense, detoxification and many other processes that require glutathione.
Glutathione is also exported outside the cells where it is needed to protect red and white blood cells and keep GSH/GSSG ratio balanced. How much glutathione is produced and exported by cells is very tightly regulated by the enzyme glutamate-cysteine ligase (GCL), the first enzyme in the synthesis of glutathione.

Flooding the bloodstream with oral glutathione may slow down and over time even shut down the natural intracellular production because cells “detect” that excess and mistakenly perceive it as a sign that the stores are adequate. The same phenomenon can be observed with the hormones - for example, natural production of melatonin or testosterone decreases with the synthetic supplementation.

Liver is the organ where glutathione is produced at the highest rate and where most of the bloodstream glutathione comes from. Depletion of liver glutathione because of this “misinterpreting” would be devastating to health.

This concern has even been voiced by some renowned specialists:
A quote from Dr. Mercola’s article on glutathione: “Glutathione supplementation can help people with immunodeficiency but only to a certain degree, and only temporarily—kind of like recharging a dead battery. Ironically, glutathione supplements may actually interfere with your body’s own glutathione production. The human body is programmed to self-produce its own antioxidant enzymes such as glutathione… And synthetic supplementation of these compounds actually signals your body to stop its own production – which leaves you dependent on synthetic substances…” 

Glutathione is a cysteine-containing peptide found in most forms of aerobic life It is not required in the diet and is instead synthesized in cells from its constituent amino acids.[  

Glutathione has antioxidant properties since the thiol group in itscysteine moiety is a reducing agent and can be reversibly oxidized and reduced. In cells, glutathione is maintained in the reduced form by the enzyme glutathione reductase and in turn reduces other metabolites and enzyme systems, such as ascorbate in the glutathione-ascorbate cycle, glutathione peroxidases and glutaredoxins, as well as reacting directly with oxidants. Due to its high concentration and its central role in maintaining the cell's redox state, glutathione is one of the most important cellular antioxidantsIn some organisms glutathione is replaced by other thiols, such as by mycothiol in the Actinomycetes, bacillithiol in some Gram-positive bacteria, or by trypanothione in the Kinetoplastids.


Read more information about Glutathione @


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Kenali Glutathione


Kenali Glutathione

GLUTATHIONE





Glutathione adalah bahan semula jadi yang dihasilkan oleh hati. Ia juga terdapat dalam buah-buahan, sayur-sayuran, dan daging.


Kebanyakan pengguna mengambil glutathione untuk merawat katarak dan glaukoma, mencegah penuaan, merawat atau mencegah ketagihan alkohol, asma, kanser, penyakit jantung (aterosklerosis dan kolesterol yang tinggi), hepatitis, penyakit hati, penyakit yang melemahkan sistem pertahanan badan (termasuk AIDS dan keletihan kronik sindrom), kehilangan ingatan, penyakit Alzheimer, osteoartritis, dan penyakit Parkinson. Glutathione juga digunakan untuk mengekalkan sistem pertahanan badan (sistem imun) dan menentang keracunan bahan kimia dan juga dadah yang berlebihan.



Perawat kesihatan akan memberikan suntikan glutathione untuk mencegah kesan sampingan beracun dalam rawatan kanser (kemoterapi). Selain itu, glutathione juga digunakan untuk merawat masalah ketidakupayaan dan ketidaksuburan lelaki.


Dalam penjagaan kecantikan dan kesihatan juga, glutathione diberi melalui suntikan ke intravena (melalui suntikan ke dalam vena itu, melalui IV) untuk mencegah (anemia) pada pesakit buah pinggang yang menjalani rawatan hemodialisis, mencegah masalah buah pinggang selepas pembedahan pintasan jantung, merawat penyakit Parkinson, meningkatkan aliran darah dan mengurangkan pembekuan darah berlaku pada individu (aterosklerosis), merawat kencing manis, dan mencegah kesan sampingan toksik kemoterapi.


Bagaimana ia berfungsi?
Glutathione terlibat dalam banyak proses dalam tubuh manusia, termasuk bangunan dan pembaikan tisu, membuat bahan kimia dan protein yang diperlukan dalam badan, dan untuk sistem imun.


KEBAIKAN GLUTATHIONE


Fungsi Glutathione yang dapat dirasakan secara langsung dan ketara dari luaran adalah merupakan kesan sampingan daripadapeningkatan kesihatan tubuh secara menyeluruh kerana meningkatnya paras Glutathione dalam tubuh antaranya :

Meningkatkan kecerahan warna kulit (memutihkan) seluruh badan. Ini kerana kesan pemutihan terjadi dengansangat baik.Melembutkan dan menghaluskan tektur kulit (glowing).Kulit menjadi kenyal anjal.Memelihara kesihatan rambut & kuku.


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Antioxidant - Glutathione

An antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction involving the loss of electrons or an increase in oxidation state. Oxidation reactions can produce free radicals. In turn, these radicals can start chain
reactions. When the chain reaction occurs in a cell, it can cause damage or death to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are oftenreducing agents such as thiolsascorbic acid (vitamin C), or polyphenols.
Although oxidation reactions are crucial for life, they can also be damaging; plants and animals maintain complex systems of multiple types of antioxidants, such as glutathionevitamin Cvitamin A, and vitamin E as well as enzymessuch as catalasesuperoxide dismutase and various peroxidases. Insufficient levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells. Oxidative stress is damage to cell structure and cell function by overly reactive oxygen-containing molecules and chronic excessive inflammation. Oxidative stress seems to play a significant role in many human diseases, including cancers. The use of antioxidants inpharmacology is intensively studied, particularly as treatments for stroke andneurodegenerative diseases. For these reasons, oxidative stress can be considered to be both the cause and the consequence of some diseases.


Antioxidants are widely used in dietary supplements and have been investigated for the prevention of diseases such as cancer, coronary heart disease and altitude sickness. Although initial studies suggested that antioxidant supplements might promote health, later large trials including of beta-carotene, vitamin A, and vitamin E singly or in different combinations suggest that supplementation has no effect on mortality or possibly increases it. Randomized trials of taking antioxidants including beta carotene, vitamin E, vitamin C and selenium have shown no effect on cancer risk or have increased cancer risk. Supplementation with selenium or vitamin E does not reduce the risk of cardiovascular disease
Antioxidants also have many industrial uses, such as preservatives in food and cosmetics and to prevent the degradation of rubber and gasoline.
Glutathione is a cysteine-containing peptide found in most forms of aerobic life It is not required in the diet and is instead synthesized in cells from its constituentamino acids.[  Glutathione has antioxidant properties since the thiol group in itscysteine moiety is a

reducing agent and can be reversibly oxidized and reduced. In cells, glutathione is maintained in the reduced form by the enzyme glutathione reductase and in turn reduces other metabolites and enzyme systems, such as ascorbate in the glutathione-ascorbate cycle, glutathione peroxidases andglutaredoxins, as well as reacting directly with oxidants. Due to its high concentration and its central role in maintaining the cell's redox state, glutathione is one of the most important cellular antioxidantsIn some organisms glutathione is replaced by other thiols, such as by mycothiol in the Actinomycetes, bacillithiol in some Gram-positive bacteria, or by trypanothione in the Kinetoplastids.
The glutathione system includes glutathione, glutathione reductase, glutathione peroxidases and glutathione S-transferases. This system is found in animals, plants and microorganisms. Glutathione peroxidase is an enzyme containing four selenium-cofactors that catalyzes the breakdown of hydrogen peroxide and organic hydroperoxides. There are at least four different glutathione peroxidase isozymes in animals Glutathione peroxidase 1 is the most abundant and is a very efficient scavenger of hydrogen peroxide, while glutathione peroxidase 4 is most active with lipid hydroperoxides. Surprisingly, glutathione peroxidase 1 is dispensable, as mice lacking this enzyme have normal lifespans, but they are hypersensitive to induced oxidative stress. In addition, the glutathione S-transferases show high activity with lipid peroxides.  These enzymes are at particularly high levels in the liver and also serve indetoxification metabolism.

A part of Glutathione  Testimoni


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Glutathione is a Master Antioxidant

Glutathione is a Master Antioxidant

Glutathione is a Master Antioxidant
      This new old “wonder” supplement is called Glutathione. Glutathione is an amino-acid that has been known to help the body fight free radicals produced from pollutants found in the air, food and water. Today, it is more popularly known and much sought after for its skin lightening benefits. In increased dose, it is said to have a remarkable good ‘side effect’ on the skin: skin whitening and other skin enhancing and nourishing benefits.
     Dermatologists prescribe it to remove dark spots, prevent or get rid of pimples and pimple marks, take away or prevent wrinkles, and other beauty-related treatments. Its skin whitening regimen is widely used in Asia and has been reported to be the “Asia’s Most Prescribed Oral Skin Whitener” among the skin whitening products. It is often referred to as bleaching pill, bleaching capsule, whitening pill or whitening capsule. Many dermatologists use it.
     Oral administration of this supplement, taking in consideration the proper dosage, is said to help lighten one’s skin and give it a youthful sheen. How it works as skin whitener The inner layer of the skin called dermis and the outer surface which is visible to our eyes is the epidermis. The primary element that determines the color of human skin is the amount of melanin in the skin. And melanin is produced by a cell called melanocyte. In increased dose, glutathione helps whiten the skin by reducing melanocytes which then leads to reduction of melanin in the skin, making it look fairer. But this is not an overnight fix. It takes a little time to see initial change in one’s skin tone. That’s because glutathione’s whitening process starts from inside the skin (dermal layer) going outward (epidermal layer).
     The whitening process goes head to foot, meaning that one will have an evenly white skin tone in her whole body. It is estimated that by taking 2 capsules of 1000mg glutathione per day, one can see the results in two weeks time. However if one takes 1000mg once a day only, it would take a month for her to see and feel the results. Glutathione and Vitamin C Glutathione can be taken anytime of the day, preferably before meal time because it is best utilized when taken in an empty stomach. When one takes
     Glutathione supplements however, it is very likely that the body will oxidize the Glutathione. “Oxidized Glutathione” reduces the effectiveness Glutathione as an anti-oxidant, anti-aging or a skin whitening agent. This “oxidation process” can be prevented by taking Vitamin C. Not only that, Vitamin C also helps raise the level of Glutathione by helping the body manufacture it. According to recent research, a person taking Glutathione should take two to three times more Vitamin C (ascorbic acid) than the dose of Glutathione.
     More than just a beauty product The recent popularity of Glutathione as a wonder skin whitener has overshadowed its other health boosting benefits! Unlike any other whitening pills / capsules, glutathione doesn’t just whiten the skin, it is also an anti oxidant and anti-aging pill which is important for overall good health and long life. A closer look at glutathione What exactly is this wonder nutrient? Glutathione is a small protein composed of 3 amino acids called cysteine, glutamic acid and glycine to help the body respond to the environment such as pollution in the air we breath, water we drink, chemicals and pesticides in the food we eat that cause damages in our cells and system.
     Dubbed as the Master Antioxidant, it regulates the actions of lesser antioxidants such as vitamin C, and vitamin E within the body. It is present mostly in liver where it detoxifies many harmful compounds which are then excreted through the bile, red and white blood cells, lungs and intestinal tract. A major free radical scavenger enzyme, it helps prevent cancer especially liver cancer, essential for the functioning of the immune system, protect individual cell and tissues of arteries, brain, heart, immune cells, and kidneys. Anti-viral too Paul Cheney, M.D., Ph.D. and expert in the treatment of Chronic Fatigue Syndrome says that “Glutathione has potent anti-viral properties – if tissue and serum glutathione levels are significantly increased, the replication of most pathogens are slowed or stopped. Conversely, glutathione deficiency produces a pro-viral effect.” Sources that boost your body’s natural production of Glutathione. Glutathione is manufactured inside our cells.
     Our cell’s ability to make glutathione is directly determined by the supply of raw materials, in particular, the amino acid cysteine. Cysteine can be found in meat, red peppers, garlic, onions, broccoli, brussel sprouts, oats, milk, whey protein, and wheat germ. However, it can usually be produced by the human body under normal physiological conditions if a sufficient quantity of methionine is available. When your body is deficient in glutathione Without the protection of Glutathione, our cells will die at a faster rate, making us age quicker and putting us at risk for all kinds of toxin-induced diseases. A deficiency of glutathione can cause destruction of red blood cells, leading to anemia and oxidative stress and brain cell death and Parkinson’s Disease.
     Other health conditions that are associated with glutathione deficiency include diabetes, low sperm counts, liver disease, cataracts, and HIV infection, respiratory distress syndrome, cancer, and idiopathic pulmonary fibrosis. A research study done by Eric Topol, MD and published in the New England Journal of Medicine suggests that abnormally low glutathione levels may increase the risk of heart attack. Bad news for smokers, too, Cigarette smoking helps reduce the level of glutathione in the body. Reduced levels of glutathione increase the risk of health problems and health problems deplete the supply of glutathione in the body. It’s a vicious cycle. Side Effects What about serious side-effects?
     Studies show that there have been no noted untoward side effects of Glutathione. In fact as we noted earlier, SKIN WHITENING is the “SIDE-EFFECT” of Glutathione! So it is probably safe to add Glutathione to your daily habit of taking supplements. In fact, it’s not only safe, it will make your vitamins and other nutrients work even better because Glutathione is the master oxidant. Overdose? No danger, because, the more you take glutathione, the lighter your skin will appear!

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